Hair Loss Treatment

The hair follicle has 3 stages of growth and regrowth: Theseare anagen, catagen and telogen. the hair follicles undergoes involution, which to a large extent reflects coordinated keratinocyte apoptosis in the regressing proximal hair bulb. In mice, the steady state mRNA levels for some of the gene products implicated in the control of apoptosis, i.e., Fas, transforming growth factor (TGF-beta) and tumor necrosis factor (TNF-beta), incraese when a follicle enters into anagen-catagen-telogen transformation of the hair cycle. In sheep, the infusion of epidermal growth factor induces synchronized catagen hairloss by triggering massive apoptosis in the proximal hair bulb , and multiple additional signaling molecules have been implicated in the control of catagen, i.e., fibroblast growth factor, TGF-beta, insulin-like growth factor, parathyroid hormone related peptide….