Hair Loss Treatment

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Hair Loss and Hair loss Treatment at the Proctor Clinic

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Regen Med. 2009;4:667

Hair follicle neogenesis induced by cultured human scalp dermal papilla cells.
Qiao J,-et al

AIM: To develop a method by which human hair follicle dermal papilla (DP) cells can be expanded in vitro while preserving their hair-regrowth potential for use in follicular cell implantation, a cellular therapy for the treatment of hair loss. DP cells were isolated from scalp hair follicles in biopsies from human donors. DP cell cultures were established under conditions that preserved their hair-inductive potential and allowed for significant expansion. The hair-inductive potential of cells cultured for approximately 36 doublings was tested in an in vivo flap-graft model. In some experiments, DiI was used to label cells prior to grafting. RESULTS: Under the culture conditions developed, cultures established from numerous donors reproducibly resulted in an expansion that averaged approximately five population doublings per passage. Furthermore, the cells consistently induced hair formation in an in vivo graft assay. Grafted DP cells appeared in DP structures of newly formed hairs, as well as in the dermal sheath and in the dermis surrounding follicles. Induced hair follicles persisted and regrew after being plucked 11 months after grafting. A process for the propagation of human DP cells has been developed that provides significant expansion of cells and maintenance of their hair-regrowth inductive capability, overcoming a major technical obstacle in the development of follicular cell implantation as a treatment for hair loss.

Lasers Surg Med.2008;40:520.

Roosen GF,et al

We have recently shown that repeated low fluence photoepilation with intense pulsed light leads to effective but reversible hair loss. Contrary to permanent hair removal treatments, LFP does not induce severe damage to the hair follicle. The purpose of the current study is to investigate the impact of LFP on the structure and the physiology of the hair follicle. Single pulses of IPL with a fluence of 9 J/cm(2) and duration of 15 milliseconds were applied to one lower leg of 12 female subjects, followed by taking a single biopsy per person, either immediately, or after 3 or 7 days. snip.. RESULTS: The majority of the cultured follicles that had been exposed to LFP treatment showed a marked treatment effect. The melanin containing part of the hair follicle bulb was the target and a catagen-like transformation was observed demonstrating that hair formation had ceased. The other follicles that had been exposed to LFP showed a less strong or no response. The skin biopsies also revealed that the melanin-rich region of the hair follicle bulb matrix was targeted; other parts of the follicle and the skin remained unaffected. Catagen/telogen hair follicles were visible with unusual melanin clumping, indicating this cycle phase was induced by the IPL treatment. CONCLUSIONS: Low fluence photoepilation treatment targets the pigmented matrix area of hair follicle bulb, causing a highly localized but mild trauma that interrupts the hair cycle ..,and eventually leads to temporary loss of the hair.

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List of Hair loss treatment blogs

Hair loss treatment blog

Hair loss treatment blog

Hair loss blog

hair loss treatment at the Proctor clinic

Hair regrowth and hair loss

Dermatol Surg. 2009;35:170

Contemporary hair transplantation.
Avram M, Rogers N.

The field of hair transplantation has evolved considerably over the last quarter century. Performed correctly, the cosmetic results of contemporary hair transplantation are virtually undetectable in women and men. Large, pluggy “punch grafts” have been replaced with natural-appearing follicular unit grafts, which maintain their existing anatomy and with proper technique can match the orientation of surrounding hair follicles. OBJECTIVE: To review all of the steps involved in hair transplantation surgery and to provide an overview of medications used in conjunction with transplantation to help prevent hair loss. The authors review key aspects of the consultation, physical examination, selection of appropriate candidates, excision of donor area, hairline design, graft creation and placement, and postoperative instructions. The role of medications such as minoxidil and finasteride in preventing ongoing hair loss is an essential part of the treatment plan. For nonsurgical candidates, other treatments such as wigs, hairpieces, and camouflages are reviewed. Future trends may involve the use of low-level laser light therapy, dutasteride, and cloning of follicles. CONCLUSION: Patients and physicians alike are pleased with the results of contemporary hair transplantation, and physicians can now recommend the procedure without reservation. The authors have indicated no significant interest with commercial supporters.

The hair follicle has 3 stages of growth and regrowth: Theseare anagen, catagen and telogen. the hair follicles undergoes involution, which to a large extent reflects coordinated keratinocyte apoptosis in the regressing proximal hair bulb. In mice, the steady state mRNA levels for some of the gene products implicated in the control of apoptosis, i.e., Fas, transforming growth factor (TGF-beta) and tumor necrosis factor (TNF-beta), incraese when a follicle enters into anagen-catagen-telogen transformation of the hair cycle. In sheep, the infusion of epidermal growth factor induces synchronized catagen hairloss by triggering massive apoptosis in the proximal hair bulb , and multiple additional signaling molecules have been implicated in the control of catagen, i.e., fibroblast growth factor, TGF-beta, insulin-like growth factor, parathyroid hormone related peptide….

Uric acid and Stroke

This is Dr Proctor’s paper on the relationship between uric acid and stroke. many of the same processes that happen in hair loss also figure in stroke causation. Similarly, many agents that are effective in hair loss and hair loss treatment are also effective in experimental models of stroke.

Protection, regeneration and replacement of hair cells in the cochlea: implications for the future treatment of sensorineural hearing loss

Bodmer D Swiss Med Wkly 2008;138:708

Review article

Summary
In the last few years progress has been made in understanding basic mechanisms involved in damage to the inner ear and various potential therapeutic approaches have been developed. It was shown that hair cell loss mediated by noise or toxic drugs may be prevented by antioxidants, inhibitors of intracellular stress pathways and neurotrophic factors/neurotransmission blockers. Moreover, there is hope that once hair cells are lost, their regeneration can be induced or that stem cells can be used to build up new hair cells. However, although tremendous progress has been made, most of the concepts discussed in this review are still in the “animal stage” and it is difficult to predict which approach will finally enter clinical practice. In my opinion it is highly probable that some concepts of hair cell protection will enter clinical practice first, while others, such as the use of stem cells to restore hearing, are still far from clinical utility.